Necrotizing enterocolitis (NEC) is a significant cause of morbidity and mortality in premature infants, with Tennessee’s NEC rate ranging from 3% to 10% annually. This project aims to reduce the NEC incidence by 25% and mortality by 10% by 2026 among preterm infants born at 29.6 or less weeks gestation. By implementing evidence-based practices and leveraging quality improvement methodologies, this initiative will standardize care across NICUs, optimize clinical outcomes, and enhance neonatal care statewide.